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AIRE antibody - middle region
Instruction Manual!
| Product name: | AIRE antibody - middle region |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Applications: | WB |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-AIRE polyclonal antibody - middle region
Catalog Number：IC105551
Product Profile
| ProductName | Rabbit anti-AIRE polyclonal antibody - middle region |
|---|---|
| AntibodyType | Primary Antibodies |
| Immunogen |
The immunogen for anti-AIRE antibody: synthetic peptide directed towards the middle region of human AIRE |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | AIRE |
|---|---|
| Gene Synonyms |
AIRE1
More
APECED APS1 APSI PGA1 |
| Gene Full Name | Autoimmune regulator |
| Gene Summary |
The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
More
|
| Alternative Names |
AIRE1
More
APECED APS1 APSI PGA1 |
| MolecularWeight(MW) | 58kDa |
| Sequence | 545 amino acids |
Database Links
| Entrez Gene | 326 |
|---|---|
| SwissProt ID | O43918 |
| Protein Accession | NP_000374 |
Application
-
Western blot
0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Placenta
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
