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CXCR4 antibody - N-terminal region
Instruction Manual!
| Product name: | CXCR4 antibody - N-terminal region |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Applications: | FCIHCWB |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-CXCR4 polyclonal antibody - N-terminal region
Catalog Number：IC105220
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Product Profile
| ProductName | Rabbit anti-CXCR4 polyclonal antibody - N-terminal region |
|---|---|
| AntibodyType | Primary Antibodies |
| Immunogen |
The immunogen for anti-CXCR4 antibody: synthetic peptide directed towards the N terminal of human CXCR4 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | CXCR4 |
|---|---|
| Gene Synonyms |
CD184
More
D2S201E FB22 HM89 HSY3RR LAP3 LCR1 LESTR NPY3R NPYR NPYRL NPYY3R WHIM |
| Gene Full Name | Chemokine (C-X-C motif) receptor 4 |
| Gene Summary |
CXCR4 is a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
More
|
| Alternative Names |
CD184
More
D2S201E FB22 HM89 HSY3RR LAP3 LCR1 LESTR NPY3R NPYR NPYRL NPYY3R WHIM |
| MolecularWeight(MW) | 40kDa |
| Sequence | 352 amino acids |
Database Links
| Entrez Gene | 7852 |
|---|---|
| SwissProt ID | P61073 |
| Protein Accession | NP_003458 |
Application
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Immunohistochemical
Sample Type: human colon tissues infected ex-vivo with HIV-1
Green: Primary
Blue: DAPI
Primary Dilution: 1:100
Secondary Antibody: Donkey anti-Rabbit AF 488
Secondary Dilution: 1:500
Image Submitted By: Chiara Foglieni
San Raffaele Scientific Institute, Milan, Italy -
Immunohistochemistry
Immunohistochemistry with HMEC-1 and A549 cells tissue
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Western blot
Positive Control: Lane 1: 20ug mouse brain extract Lane 2: 20ug mouse brain extract
Primary Antibody Dilution : 1:500
Secondary Antibody : Anti rabbit-HRP
Secondry Antibody Dilution : 1:5,000
Submitted by: Scott Wilson, University of Alabama at Birmingham -
Western blot
CXCR4 antibody - N-terminal region validated by WB using 721_B cell Lysate at 0.2-1 ug/ml.
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Western blot
CXCR4 antibody - N-terminal region validated by WB using human microvascular endothelial cells (25ug) at 1:1000.
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Western blot
0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysate
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
