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PARP-1 Antibody

PARP-1 Antibody PARP-1 Antibody

Instruction Manual!

Product name: PARP-1 Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Liquid. Contains 0.1% sodium azide.
Applications:ICCIHCIPWB
Storage:Stable for at least 1 year after receipt when stored at -20˚C.
UOM:100ug

PARP-1 Antibody

Catalog Number:IC287372

Product Profile

Product Name PARP-1 Antibody
Antibody Type Primary Antibodies
Productdescription 
							
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
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Immunogen
Recombinant mouse PARP-1 [ARTD1] (aa 215-525).

Key Feature

Clonality Polyclonal
Host Species Rabbit
TestedApplications 

ICCIHCIPWB

Immunocytochemistry: 1:500-1:1,000 . Immunohistochemistry: 1:500-1:1,000 . Immunoprecipitation: 2ul per 100ug nuclear extract . Western Blot: 1:2,000-1:5,000 . Optimal conditions must be determined individually for each application.:
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Species Reactivity

HumanMouse

Concentration 1mg/ml
Purification

Target Information

Gene Symbol Parp1
Alternative Names
Poly(ADP-ribose) Polymerase 1
ADP-ribosyltransferase Diphtheria Toxin-like 1
NAD(+) ADP-ribosyltransferase 1
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Tissue Specificity Recognizes mouse PARP-1. Cross-reacts weakly with human PARP-1.

Database Links

Entrez Gene 11545
Protein Accession P11103

Application

ApplicationNotes 
Immunocytochemistry: 1:500-1:1,000 . Immunohistochemistry: 1:500-1:1,000 . Immunoprecipitation: 2ul per 100ug nuclear extract . Western Blot: 1:2,000-1:5,000 . Optimal conditions must be determined individually for each application.:
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Additional Information

Form Liquid
Storage Instructions Stable for at least 1 year after receipt when stored at -20˚C.
Storage Buffer Liquid. Contains 0.1% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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