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Casp3 Antibody - middle region
Instruction Manual!
| Product name: | Casp3 Antibody - middle region |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Applications: | WB |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-Casp3 Antibody - middle region
Catalog Number：IC118659
Product Profile
| ProductName | Rabbit anti-Casp3 Antibody - middle region |
|---|---|
| AntibodyTyp | Primary Antibodies |
| Immunogen |
The immunogen for Anti-Casp3 antibody is: synthetic peptide directed towards the middle region of Mouse Casp3 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | Casp3 |
|---|---|
| Gene Synonyms |
A830040C14Rik
More
AC-3 Apopain CC3 CPP32 Caspase-3 Lice Yama mldy |
| Gene Full Name | caspase 3, apoptosis-related cysteine peptidase |
| Gene Summary |
Casp3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain, cleaves and activates caspase-6, -7 and -9, triggers cell adhesion in sympathetic neurons through RET cleavage, cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
More
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| Alternative Names |
A830040C14Rik
More
AC-3 Apopain CC3 CPP32 Caspase-3 Lice Yama mldy |
| MolecularWeight(MW) | 31kDa |
| Sequence | 277 amino acids |
Database Links
| Entrez Gene | 12367 |
|---|---|
| SwissProt ID | P70677 |
| Protein Accession | NP_033940 |
Application
-
Western blot
Host: Rabbit
Target Name: Casp3
Sample Tissue: Mouse Liver lysates
Antibody Dilution: 1.0ug/ml
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
