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Trk A (phospho Tyr757) Antibody

Trk A (phospho Tyr757) Antibody Trk A (phospho Tyr757) Antibody

Instruction Manual!

Product name: Trk A (phospho Tyr757) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHC
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

Trk A (phospho Tyr757) Antibody

Catalog Number:IC294140

Product Profile

Product Name Trk A (phospho Tyr757) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.1) Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).
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Immunogen
Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p)-A-I) derived from Human Trk A.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IHC

Species Reactivity

HumanMouse

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol NTRK1
Alternative Names
TRKA
TRK
NTRK1
p140-TrkA
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MolecularWeight(MW)  87 kDa
Tissue Specificity The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757.

Database Links

Entrez Gene 4914
Protein Accession NP_002520.2

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody (left) or the same antibody preincubated with blocking peptide (right).

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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