elisa kit elisa kits logo

Tel:631-424-0089
Fax:631-424-0095
Email: info@immunoclone.com

Home>>Products >>  New Products

BRCA1 (phospho Ser1457) Antibody

BRCA1 (phospho Ser1457) Antibody BRCA1 (phospho Ser1457) Antibody

Instruction Manual!

Product name: BRCA1 (phospho Ser1457) Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:WB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

BRCA1 (phospho Ser1457) Antibody

Catalog Number:IC272680

Product Profile

Product Name BRCA1 (phospho Ser1457) Antibody
Antibody Type Primary Antibodies
Productdescription 
							
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation1) Miki Y., Science 266:66-71(1994).
More 
Immunogen
BRCA1 (phospho Ser1457) antibody was raised against a peptide sequence around phosphorylation site of Serine 1457 (L-T-S (p)-Q-K) derived from Human BRCA1.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB

Western Blot: 1:500~1:1000:
Species Reactivity

Human

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol BRCA1
Alternative Names
BRCA1
Breast cancer type 1 susceptibility protein
familial breast/ovarian cancer gene 1
More 
MolecularWeight(MW)  220 kDa
Tissue Specificity The antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1457.

Database Links

Entrez Gene 672
Protein Accession NP_009225.1

Application

  • Application

    Western blot analysis of extracts from 293 cells (Lane 2), using BRCA1 (Phospho-Ser1457) Antibody. The lane on the left is treated with antigen-specific peptide.

Application Notes
Western Blot: 1:500~1:1000:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

Copyright @ USA Immuno Clone Co., Ltd(I&C) All Rights Reserved Language:Chinese