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4E BP1 Antibody

4E BP1 Antibody 4E BP1 Antibody

Instruction Manual!

Product name: 4E BP1 Antibody
Source:Rabbit
Purity:>95%
Buffer Formulation:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Applications:IHCWB
Storage:Store antibody at -20˚C for up to one year.
UOM:100ug

4E BP1 Antibody

Catalog Number:IC269417

Product Profile

Product Name 4E BP1 Antibody
Antibody Type Primary Antibodies
Productdescription 
							
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.1) Gingras AC, et al. Genes Dev Nov. 2005 Feb 15. Mothe-Satney I, et al. (2000) J Biol Chem:15 (21): 2852-64. Gingras AC, et al. (1999) Genes Dev:13 (11): 1422-37. Lal L, et al. (2005) Blood;105 (4): 1669-7.
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Immunogen
4E-BP1 (Ab-36) antibody was raised against a peptide sequence around aa.34~38 (S-T-T-P-G) derived from Human 4E-BP1.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHCWB

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Gene Symbol EIF4EBP1
Alternative Names
BP-1
4EBP1
4E-BP1
PHAS-I
Trp6
Trrp6
EIF4EBP1
PHAS-1
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Molecular Weight(MW) 18 kDa
Tissue Specificity This antibody detects endogenous level of total 4E-BP1 protein.

Database Links

Entrez Gene 1978
Protein Accession NP_004086.1

Application

  • Application

    Western blot analysis of lysed extracts from HepG2 and 293 cells using 4E-BP1 (Ab-36).

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 4E-BP1 (Ab-36).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
StorageInstructions  Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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