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EAP30 antibody
Instruction Manual!
| Product name: | EAP30 antibody |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol |
| Applications: | WB IHC |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-EAP30 polyclonal antibody - N-terminal region
Catalog Number：IC105378
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Product Profile
| ProductName | Rabbit anti-EAP30 polyclonal antibody - N-terminal region |
|---|---|
| AntibodyType | Primary Antibodies |
| Immunogen |
The immunogen for anti-EAP30 antibody: synthetic peptide directed towards the N terminal of human EAP30 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | EAP30 |
|---|---|
| Gene Synonyms |
Dot3
EAP30 VPS22 |
| Gene Full Name | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) |
| Gene Summary |
ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].
More
|
| Alternative Names |
Dot3
EAP30 VPS22 |
| MolecularWeight(MW) | 29kDa |
| Sequence | 258 amino acids |
Database Links
| Entrez Gene | 11267 |
|---|---|
| SwissProt ID | Q96H20 |
| Protein Accession | NP_009172 |
Application
-
Immunohistochemical
Human Spleen
-
Immunohistochemical
Human Heart
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Western blot
5.0ug/ml
Positive Control: HepG2 cell lysate
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
