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MAP3K8 antibody
Instruction Manual!
| Product name: | MAP3K8 antibody |
| Source: | Rabbit |
| Purity: | >95% |
| Buffer Formulation: | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Applications: | WB |
| Storage: | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| UOM: | 100ug |
Rabbit anti-MAP3K8 polyclonal antibody - C-terminal region
Catalog Number：IC105203
Product Profile
| ProductName | Rabbit anti-MAP3K8 polyclonal antibody - C-terminal region |
|---|---|
| AntibodyType | Primary Antibodies |
| Immunogen |
The immunogen for anti-MAP3K8 antibody: synthetic peptide directed towards the C terminal of human MAP3K8 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
| Species Reactivity | |
| Concentration | 1mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | MAP3K8 |
|---|---|
| Gene Synonyms |
COT
More
EST ESTF TPL2 MEKK8 Tpl-2 c-COT |
| Gene Full Name | Mitogen-activated protein kinase kinase kinase 8 |
| Gene Summary |
MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
More
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| Alternative Names |
COT
More
EST ESTF TPL2 MEKK8 Tpl-2 c-COT |
| MolecularWeight(MW) | 53kDa |
| Sequence | 467 amino acids |
Database Links
| Entrez Gene | 1326 |
|---|---|
| SwissProt ID | P41279 |
| Protein Accession | NP_005195 |
Application
-
Western blot
2.5ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
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